This medication will trigger constipation. If you don't Use a bowel motion for three days, connect with your treatment staff.
For prescriptions wherever a measuring unit just isn't supplied, a pharmacist can provide an ideal calibrated measuring unit and can offer instructions for measuring the right dose.
Get medical aid instantly Should you have any very critical side effects, such as: slow/shallow respiratory, seizures.
Promethazine is contraindicated in comatose states, and in persons regarded to be hypersensitive or to possess had an idiosyncratic reaction to promethazine or to other phenothiazines.
By way of example, quite a few reported circumstances of Dying occurred from the put up-operative time period subsequent tonsillectomy and/or adenoidectomy, and many of the children experienced proof of currently being extremely-fast metabolizers of codeine. Moreover, young children with obstructive snooze apnea who will be treated with codeine for post-tonsillectomy and/or adenoidectomy soreness might be specially delicate to its respiratory depressant influence. Due to risk of daily life-threatening respiratory despair and Loss of life:
Understand that this medication is prescribed mainly because your doctor has judged which the benefit to you personally is greater than the potential risk of Negative effects. Many people applying this medication do not have critical Negative effects.
Discontinuation of the concomitantly utilised cytochrome P450 2D6 inhibitor may well result in a minimize in codeine plasma focus and an increase in Energetic metabolite morphine plasma concentration which could enhance or extend adverse reactions and should trigger potentially fatal respiratory despair.
Recommend sufferers to always use an precise milliliter measuring product when measuring and administering Promethazine HCl and Codeine Phosphate Oral Resolution. Advise sufferers that a household teaspoon is not an correct measuring device and these use Promethazine codeine syrup could lead to overdosage and critical adverse reactions [see Overdosage (ten)].
A most likely deadly symptom complicated sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has actually been claimed in Affiliation with promethazine HCl by itself or together with antipsychotic medications.
Animal reproduction experiments have not been performed Using the drug mix-promethazine and codeine. It is not identified whether this drug mixture can result in fetal hurt when administered to the pregnant female or can have an impact on copy potential.
Simply because opioid agonists may well enhance biliary tract pressure, with resultant increase in plasma amylase or lipase stages, perseverance of these enzyme stages could be unreliable for twenty-four hours soon after administration of a dose of Promethazine HCl and Codeine Phosphate Oral Answer.
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The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals below 6 years of age, due to the fact The mixture may perhaps bring about fatal respiratory despair Within this age inhabitants. It is vital that promethazine with codeine syrup is measured having an exact measuring unit (see PRECAUTIONS-Information and facts For Sufferers).